Biosynthesis and distribution of fibronectin in normal and osteoarthritic human cartilage.
Clin Physiol Biochem
; 9(1): 1-6, 1992.
Article
em En
| MEDLINE
| ID: mdl-1424433
ABSTRACT
The biosynthesis of fibronectin was determined in explants from normal and osteoarthritic human cartilage after metabolic labeling and immunoprecipitation. Each sample of osteoarthritic cartilage was divided into three regions taken at different distances from the eburnated bone area. Only full depth cartilage samples were taken into consideration. We could detect a low level of fibronectin biosynthesis in normal cartilage. In osteoarthritic cartilage increased synthesis of fibronectin was demonstrated, the most important in the region close to the eburnated area. Increased synthesis, although to a lower extent, was also demonstrated in the two other regions at increasing distances from the eburnated areas. Immuno-histological examinations performed on tissue samples and similar studies on articular chondrocyte cell cultures confirmed the accumulation of newly synthesized fibronectin in pathological conditions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
/
Cartilagem Articular
/
Fibronectinas
Limite:
Humans
Idioma:
En
Revista:
Clin Physiol Biochem
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
França