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Retardation of cell aging by lipid peroxidation.
Zheng, R L; Zheng, T S.
Afiliação
  • Zheng RL; Department of Biology, Lanzhou University, P.R. China.
Mol Cell Biochem ; 115(1): 59-62, 1992 Sep 22.
Article em En | MEDLINE | ID: mdl-1435766
ABSTRACT
Different concentrations of Fe2+/vitamin C mixtures were used as initiators of lipid peroxidation in diploid fibroblasts from cultured human embryonic lung. Malondialdehyde (MDA) formation in the cell cultures was correlated directly with the concentrations of Fe2+ and vitamin C. Lipid peroxidation was associated with an increase in life-span, decrease in the population doubling time and increase in cellular DNA synthesis. The effects of lipid peroxidation varied inversely with the MDA level. These data showed that low levels of lipid peroxidation retarded several biological properties of cultured cells that are associated with cell aging.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Peroxidação de Lipídeos / Senescência Celular / Ferro Limite: Humans Idioma: En Revista: Mol Cell Biochem Ano de publicação: 1992 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Peroxidação de Lipídeos / Senescência Celular / Ferro Limite: Humans Idioma: En Revista: Mol Cell Biochem Ano de publicação: 1992 Tipo de documento: Article