Decrease in immunoreactivity and vasoactivity of endothelin-1 after exposure to oxygen.
Biochem Int
; 27(6): 1111-7, 1992 Sep.
Article
em En
| MEDLINE
| ID: mdl-1445378
ABSTRACT
Endothelin-1 (ET-1) caused a dose-dependent contraction of porcine coronary arterial rings. Preincubation of ET-1 in oxygenated Krebs solution at 37 degrees C resulted in a progressive loss of the contractile activity and immunoreactivity of ET-1. The half-life of ET-1 contractile activity in oxygenated and non-oxygenated buffer was 16.1 and 86.6 min., respectively. The molecular weight of ET-1 exposed to oxygen was identical to that of ET-1. These results indicate that during the contraction of smooth muscle preparations the levels of ET-1 in the tissue bath are steadily decreasing due to exposure to high pO2 levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Endotelinas
/
Músculo Liso Vascular
Limite:
Animals
Idioma:
En
Revista:
Biochem Int
Ano de publicação:
1992
Tipo de documento:
Article