Improved apparatus for solid-liquid multi-stage counter-current extraction.
J Chromatogr A
; 1017(1-2): 63-9, 2003 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-14584691
ABSTRACT
An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (+/-)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9 h), 0.1 g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1 g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Distribuição Contracorrente
Idioma:
En
Revista:
J Chromatogr A
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Japão