In-vivo antimalarial activity of some oxygenated xanthones.
Ann Trop Med Parasitol
; 97(7): 683-8, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-14613627
ABSTRACT
A series of oxygenated xanthones was prepared so that the antimalarial activity of each compound could be evaluated in vivo, using 4-day suppressive assays against Plasmodium berghei ANKA in BALB/c mice. When given in a dose of 20 mg/kg.day for 4 days, most of the compounds produced significant chemosuppression of parasitaemia. The most active compound was 1,3,6,8-tetrahydroxyxanthone, which reduced the percentage of erythrocytes infected by 70.5%, followed by norlichexanthone (44.3%) and its isomer, 1,3,8-trihydroxy-6-methylxanthone (37.0%). Whereas di-C-allyl-dihydroxyxanthone showed lower but still notable activity (33.4%), 1,3-dihydroxyxanthone was much less active (15.1%). This appears to be the first demonstration of the antimalarial activity of some hydroxyxanthones in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium berghei
/
Xantonas
/
Malária
/
Antimaláricos
Limite:
Animals
Idioma:
En
Revista:
Ann Trop Med Parasitol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Camarões