Role of Fcgamma receptors in the pathogenesis and treatment of idiopathic thrombocytopenic purpura.
J Pediatr Hematol Oncol
; 25 Suppl 1: S14-8, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14668633
ABSTRACT
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease characterized by autoantibody-mediated platelet destruction. Platelets with associated IgG are targeted for destruction by phagocytic cells bearing Fc receptors in the reticuloendothelial system. While there are a variety of therapeutics available for this incompletely understood disease, one of the treatments of choice is infusion of intravenous immunoglobulin (IVIG). This review will discuss the pathophysiology of ITP with an emphasis on the role of Fcgamma receptors in both the pathogenesis and treatment of the disease by IVIG. Other prominent theories of the mechanisms of action of IVIG, including the role of anti-idiotype antibodies, will also be addressed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Púrpura Trombocitopênica Idiopática
/
Imunoglobulinas Intravenosas
/
Receptores de IgG
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
J Pediatr Hematol Oncol
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Canadá