Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine.
Clin Infect Dis
; 37(12): e174-6, 2003 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-14689363
ABSTRACT
Tenofovir-related tubular damage, like all other recently reported cases, occurred in patients receiving the protease inhibitor (PI) ritonavir, often with lopinavir. Increased plasma concentrations of didanosine were also observed after the addition of tenofovir. It was suspected that tenofovir with PIs interacted with renal organic anion transporters, leading to nephrotoxic tubular concentrations of tenofovir and systemic accumulation of didanosine. Until there is a better understanding of these interactions, close monitoring is recommended for patients receiving tenofovir, PIs, and didanosine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenina
/
Síndrome da Imunodeficiência Adquirida
/
Diabetes Insípido Nefrogênico
/
Fármacos Anti-HIV
/
Síndrome de Fanconi
/
Organofosfonatos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Infect Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França