DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
Ann Neurol
; 55(1): 113-8, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14705119
ABSTRACT
Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Corpos de Inclusão
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Proteínas tau
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Proteínas Oncogênicas
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Transtornos Parkinsonianos
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Demência
Limite:
Aged
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Aged80
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Animals
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Humans
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Middle aged
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Holanda
País de publicação:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA