[The dependence of DNA repair induced by genetically hazardous exposures on the ionic strength of the medium containing the cells]. / Zavisimost' reparatsii DNK, indutsirovannoi geneticheski opasnymi vozdeistviiami, ot ionnoi sily sredy, v kotoroi nakhodiatsia kletki.
Tsitologiia
; 34(7): 76-85, 1992.
Article
em Ru
| MEDLINE
| ID: mdl-1475855
ABSTRACT
The dependence of UV-induced unscheduled DNA synthesis (UDS) in non-stimulated lymphocytes of human peripheral blood on the ionic strength (mu) of the culture medium has been shown. With the level of mu lower or higher than physiological (mu ph) the UDS significantly decreases. The effect of modification of mu due to changes in ionic strength is absent in the lymphocytes of patients with the classic form of xeroderma pigmentosum. This phenomenon may become useful for development of a new test revealing cells with genetically or physiologically changed system of UV-induced DNA repair. Mechanisms of investigated phenomenon, particularly their dependence on the chromatin structure, as well as the influence of ionic strength on binding the repair enzymes with DNA are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
DNA
/
Reparo do DNA
Limite:
Adult
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Ru
Revista:
Tsitologiia
Ano de publicação:
1992
Tipo de documento:
Article
País de publicação:
FEDERAÇÃO RUSSA
/
RU
/
RUSIA
/
RUSSIA