Human pharmacokinetics of an analogue of atrial natriuretic factor.
Eur J Clin Pharmacol
; 43(5): 539-41, 1992.
Article
em En
| MEDLINE
| ID: mdl-1483491
ABSTRACT
The pharmacokinetics of ANP-270, a 26 amino acid analogue of alpha human natriuretic factor (alpha-hANF) with a prolonged effect on isolated arterial preparations, has been studied in 40 healthy males, in a double-blind placebo controlled investigation. Placebo or ANP-270 0.3, 1.5 or 3.0 micrograms/kg were given by intravenous bolus injection, each to groups of 10 subjects. Blood samples were assayed for ANP-270 by a specific sandwich ELISA. The disappearance of ANP-270 from plasma followed a two-compartment decay, with mean distribution and elimination half-lives of 2.6 min (n = 30) and 10.6 min (n = 20), respectively. These estimates were similar to those obtained by other investigators for alpha-hANF. Their brevity explains the lack of a prolonged effect of ANP-270 in vivo compared to alpha-hANF.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Fator Natriurético Atrial
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Dinamarca