Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.
Arch Toxicol
; 66(3): 216-9, 1992.
Article
em En
| MEDLINE
| ID: mdl-1497487
ABSTRACT
The toxicity and efficacy of two oximes, HLö-7 and pyrimidoxime, were evaluated in mice and compared to those obtained with HI-6. HLö-7 and pyrimidoxime produced 24 h LD50 values of 356 and 291 mg/kg (i.p.), respectively. In combination with atropine (17.4 mg/kg, i.p.), HLö-7 was a very efficient therapy against poisoning by 3 x LD50 dose of soman, sarin and GF and 2 x LD50 dose of tabun with ED50 values of 12.4, 0.31, 0.32 and 25.2 mg/kg, respectively. In contrast, pyrimidoxime was a relatively poor therapy which resulted in ED50 values of greater than 150, 5.88, 100 and 71 mg/kg against poisoning by soman, sarin, GF and tabun, respectively. HLö-7 produced significant (p less than 0.05) reactivation of phosphorylated acetylcholinesterase, in vivo, resulting in 47, 38, 27 and 10% reactivation of sarin, GF, soman and tabun inhibited mouse diaphragm acetylcholinesterase, respectively. HLö-7 also antagonized sarin-induced hypothermia in mice suggesting that it reactivated central acetylcholinesterase. The potential of HLö-7 as a replacement oxime for the treatment of nerve agent poisoning is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Compostos de Piridínio
/
Inibidores da Colinesterase
/
Reativadores da Colinesterase
/
Imidazóis
/
Antídotos
/
Bloqueadores Neuromusculares
Limite:
Animals
Idioma:
En
Revista:
Arch Toxicol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Canadá