Targeting duplex DNA with DNA-PNA chimeras? Physico-chemical characterization of a triplex DNA-PNA/DNA/DNA.
Biopolymers
; 73(4): 434-42, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-14991660
ABSTRACT
Targeting double-stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA-PNA chimeras. A 16-mer 5'-DNA-3'-p-(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and molecular modeling studies. The obtained results showed the formation of a triplex structure having similar, if not slightly higher, stability compared to the same all-DNA complex.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Quimera
/
Ácidos Nucleicos Peptídicos
/
Conformação de Ácido Nucleico
Idioma:
En
Revista:
Biopolymers
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Itália