Unguioblastoma and unguioblastic fibroma--an expanded spectrum of onychomatricoma.
J Cutan Pathol
; 31(4): 307-11, 2004 Apr.
Article
em En
| MEDLINE
| ID: mdl-15005687
ABSTRACT
Onychomatricoma is a rare tumor that appears to originate from cells of the nail matrix. Three cases of onychomatricoma that met Perrin et al.'s1 histologic criteria of onychomatricoma are described. However, using a single term to classify all three tumors ignores the apparent microscopic differences that exist among them. To demonstrate better the spectrum of so-called onychomatricoma and properly acknowledge the noticeable disparity among our cases, a series of terms is proposed. This terminology is based on the histologic spectrum of epithelial-stromal ratio of stromal cellularity and of extent nuclear pleomorphism. Use of such criteria has a precedent in the classification of follicular and odontogenic fibroepithelial neoplasms. This new nomenclature includes "unguioblastoma" for tumors with a predominant epithelial component and "unguioblastic fibroma" for tumors where a cellular stroma is more prominent and characteristic. The term "atypical unguioblastic fibroma" is used to describe a third rare neoplasm, in which the cellular stroma shows nuclear pleomorphism and atypia with an increase of mitotic activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Fibroma
/
Doenças da Unha
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos