Adenosine, inflammation and asthma--a review.
Inflamm Res
; 53(5): 171-8, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15105965
ABSTRACT
Adenosine is a ubiquitous molecule present in every cell of the human body. It has a wide range of physiological functions mediated predominantly through specific cell surface adenosine receptors. Adenosine has both pro- and anti-inflammatory effects and acts on inflammatory and resident immune cells and antioxidant enzymes. The elevation of adenosine in the bronchoalveolar lavage (BAL) fluid of asthmatics combined with its bronchoconstrictor effect on the airways in asthmatics has led to increased research into the contribution of adenosine in the pathophysiology of inflammation and asthma. This review looks at the airway response to adenosine and at the interaction of adenosine with mast cells and basophils.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Adenosina
/
Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Inflamm Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Reino Unido