Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K.
Bioorg Med Chem Lett
; 14(10): 2543-6, 2004 May 17.
Article
em En
| MEDLINE
| ID: mdl-15109647
ABSTRACT
An orally available series of ketoamide-based inhibitors of cathepsin K has been identified. Starting from a potent inhibitor with poor oral bioavailability, modifications to P1 and P1' elements led to enhancements in solubility and permeability. These improvements resulted in orally available cathepsin K inhibitors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catepsinas
/
Amidas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos