Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.
Antimicrob Agents Chemother
; 48(6): 2314-7, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15155243
ABSTRACT
To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Oligonucleotídeos
/
Ribavirina
/
Adjuvantes Imunológicos
/
Receptores de Superfície Celular
/
Células Th1
/
Proteínas de Ligação a DNA
/
Imunidade Celular
Limite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Alemanha