Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.
Acta Neurol Scand
; 110(1): 67-71, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15180809
ABSTRACT
OBJECTIVES:
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system which is widely believed to have a T-cell-mediated etiology. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) antigen molecule plays a key role in the downregulation of T-cell responses. To examine the genetic association of the CTLA-4 gene locus with MS, we analyzed an exon 1 (A49G) transition. MATERIAL ANDMETHODS:
One hundred and fifty-two MS patients and 154 controls were examined. The A/G transition was genotyped by a polymerase chain reaction followed by labeling with a SNaPshot kit and detection using a capillary genetic analyzer.RESULTS:
The genotype, allele and phenotype frequencies did not differ significantly between MS patients and controls. Those MS patients with AA and AG genotypes had 4.36 times greater risk of progressing from the relapsing-remitting to the secondary progressive form of the disease than those with the GG genotype.CONCLUSION:
The results of our study indicate that CTLA-4 (A49G) exon 1 polymorphism is associated with MS progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Ativação Linfocitária
/
Linfócitos T
/
Antígenos de Diferenciação
/
Predisposição Genética para Doença
/
Esclerose Múltipla
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Neurol Scand
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Polônia