Immunohistochemical examination of P-cadherin in bullous and acantholytic skin diseases.
Acta Derm Venereol
; 84(2): 116-9, 2004.
Article
em En
| MEDLINE
| ID: mdl-15206690
ABSTRACT
Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cellular connection between normal cells. P-cadherin is involved in the selective adhesion of epidermal cells, and is expressed only on the surfaces of the two basal layers. We examined the expression of P-cadherin in some autoimmune bullous skin diseases and Darier's disease using immunohistochemistry and found P-cadherin to be strongly upregulated. We believe the upregulation is compensatory to the primary pathophysiological events in the various bullous dermatoses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caderinas
/
Dermatopatias Vesiculobolhosas
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Derm Venereol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Hungria