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Biologically effective doses in radiotherapy of cervical carcinoma*.
Urbanski, K; Gasinska, A; Pudelek, J; Fowler, J F; Lind, B; Brahme, A.
Afiliação
  • Urbanski K; Department of Gynecological Oncology, Centre of Oncology, Krakow, Poland. z5urbans@cyf-kr.edu.pl
Neoplasma ; 51(3): 228-38, 2004.
Article em En | MEDLINE | ID: mdl-15254678
Presented study evaluates biologically effective dose (BED) in patients receiving low-medium dose-rate (LDR/MDR) brachytherapy (BRT) plus external beam radiotherapy (XRT) based on tumor cell proliferation values in cancer of the cervix patients. This study includes 229 patients treated entirely by radiotherapy at the Centre Oncology in Krakow. Doses to Point A were estimated for total treatment for each brachytherapy insertion. BED3 were calculated for reference points in the rectum. The linear quadratic equation was used to calculate BED, which is proportional to log cell kill, and the normalized total dose (NTD), that is, equivalent to a 2 Gy fraction schedule. In BEDs 10 calculation overall treatment time for each patient. Tumor proliferation rate was based on Bromodeoxyuridine labeling index (BrdUrdLI) assessed on biopsy material before beginning the radiotherapy. Total BED at those points was summed for each patient. The medium overall treatment time was 90 days (range 30--210). The mean calculated total BED for point A for tumour and "early reactions" was equal to 104.0 Gy10 and 229.0 Gy3 for the rectum, equivalent to NTD=86.6 Gy and 137.4 Gy in 2 Gy fractions, respectively. Kaplan-Meier analysis revealed that age >50 years, higher than mean BRBEDs and totBEDs doses, gaps in treatments shorter than 40 days and disease free survival (DFS) was significant prognostic factor for overall survival. In the multivariate Cox anaysis age >50 years, BRBED10 >77 Gy and gaps ?40 days appeared to be significant for overall survival. None of the examined parameters was significant for tumor control. However, patients age and shorter gaps in the treatment were predictive for DFS.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias do Colo do Útero / Estadiamento de Neoplasias Tipo de estudo: Prognostic_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Neoplasma Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Polônia País de publicação: Eslováquia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias do Colo do Útero / Estadiamento de Neoplasias Tipo de estudo: Prognostic_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Neoplasma Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Polônia País de publicação: Eslováquia