Aminotriazine 5-HT7 antagonists.

Mattson, Ronald J; Denhart, Derek J; Catt, John D; Dee, Michael F; Deskus, Jeffrey A; Ditta, Jonathan L; Epperson, James; Dalton King, H; Gao, Aiming; Poss, Michael A; Purandare, Ashok; Tortolani, David; Zhao, Yufen; Yang, Hua; Yeola, Suresh; Palmer, Jane; Torrente, John; Stark, Arlene; Johnson, Graham

Mattson, Ronald J; Denhart, Derek J; Catt, John D; Dee, Michael F; Deskus, Jeffrey A; Ditta, Jonathan L; Epperson, James; Dalton King, H; Gao, Aiming; Poss, Michael A; Purandare, Ashok; Tortolani, David; Zhao, Yufen; Yang, Hua; Yeola, Suresh; Palmer, Jane; Torrente, John; Stark, Arlene; Johnson, Graham.

Afiliação

Mattson RJ; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA. mattsonr@bms.com

Bioorg Med Chem Lett ; 14(16): 4245-8, 2004 Aug 16.

Article em En | MEDLINE | ID: mdl-15261279

ABSTRACT

ABSTRACT

The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist.

Assuntos

Receptores de Serotonina/efeitos dos fármacos; Antagonistas da Serotonina/farmacologia; Triazinas/farmacologia; Relação Dose-Resposta a Droga

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antagonistas da Serotonina / Triazinas / Receptores de Serotonina Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Estados Unidos

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