Rat tail skin temperature regulation by estrogen, phytoestrogens and tamoxifen.
Maturitas
; 48(4): 463-71, 2004 Aug 20.
Article
em En
| MEDLINE
| ID: mdl-15283940
ABSTRACT
OBJECTIVE:
Develop a rat model for the evaluation of estrogenic agents on estrogen deficiency-induced changes in thermoregulation.METHODS:
OVX rats are impaired in thermoregulation which manifests itself as an elevation in basal tail skin temperature (TST) and are less able to respond to temperature changes than intact rats.RESULTS:
Administration of estrogen subcutaneously to estrogen-depleted rats either as depot formulation, biodegradable pellets, or daily injections, suppressed the increased TST. OVX rats maintained on a diet devoid of phytoestrogens had a higher TST by several degrees than OVX rats fed normal chow, offering greater ability to test estrogenic agents on thermoregulation. Depletion of estrogen in intact rats via chronic administration of leuprolide acetate, a GnRH agonist, also increased TST, which was in turn suppressed by estrogen. In intact rats, tamoxifen exhibited estrogen antagonistic activity elevating TST, while in OVX rats, tamoxifen acted as an agonist by suppressing TST.CONCLUSION:
OVX rats kept on a diet devoid of phytoestrogens are a sensitive model for estrogen-dependent thermoregulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Temperatura Cutânea
/
Cauda
/
Tamoxifeno
/
Fitoestrógenos
/
Estrogênios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Maturitas
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos