The factor V G1691A mutation is a risk for porencephaly: A case-control study.
Ann Neurol
; 56(2): 287-90, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15293282
ABSTRACT
This study was initiated to investigate prothrombotic risk factors in children with porencephaly. 76 porencephalic and 76 healthy infants were investigated for factor V (FV) G1691A mutation, factor II G20210A variant, methylenetetrahydrofolate reductase (MTHFR) C677T genotype, lipoprotein (a), protein C, protein S, and antithrombin. Only the FV mutation (p = 0.005) and combinations of two or three different risk factors (p = 0.003) were significantly associated with porencephaly. These data give evidence that the FV G1691A mutation and a combination of prothromboic factors play a major role in the development of childhood porencephaly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
Fator V
/
Predisposição Genética para Doença
/
Mutação
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Alemanha