[Immunopathogenesis of diabetes mellitus I]. / Imunopatogeneze diabetes mellitus I. typu.
Vnitr Lek
; 50(5): 408-11, 2004 May.
Article
em Cs
| MEDLINE
| ID: mdl-15305642
ABSTRACT
The pathogenesis of diabetes mellitus I is multifactorial. Both genetic predisposition and environmental factors are involved in the deregulation of immune system with subsequent breakage of self-tolerance. Autoantibodies against numerous autoantigens are raised during this long-term process but the principal pathogenic mechanism is cytotoxic killing of beta cells of pancreas mediated predominantly by T cells. There could be the chance to interrupt this pathogenetic process by manipulation with immune system to achieve induction of tolerance. Such clinical trials are now under progress.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
Limite:
Animals
/
Humans
Idioma:
Cs
Revista:
Vnitr Lek
Ano de publicação:
2004
Tipo de documento:
Article