[New technologies in the determination of drug susceptibility in Mycobacterium tuberculosis]. / Novye tekhnologii opredeleniia lekarstvennoi chuvstvitel'nosti Mycobacterium tuberculosis.
Probl Tuberk Bolezn Legk
; (6): 40-2, 2004.
Article
em Ru
| MEDLINE
| ID: mdl-15315132
ABSTRACT
A variety of mutations in the genes rpoB, katG, inhA, ahpC, kasA was studied by using different molecular biological methods (conformational polymorphism of single-chain fragments, heteroduplex analysis, biochips) in rifampicin- and isoniazid-resistant Mycobacterium tuberculosis (MBT) strains isolated from patients with pulmonary tuberculosis. Twenty-nine mutation combinations were identified in the MBT strains. The use of biochips is the most promising method for identifying the type of mutations responsible for the simultaneous resistance to rifampicin and isoniazid. Detection of several MBT strains in one patient requires the use a combination of molecular biological and microbiological studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Resistência Microbiana a Medicamentos
/
Testes de Sensibilidade Microbiana
/
Mycobacterium tuberculosis
/
Antituberculosos
Limite:
Humans
Idioma:
Ru
Revista:
Probl Tuberk Bolezn Legk
Ano de publicação:
2004
Tipo de documento:
Article