Practical synthesis of a potent hepatitis C virus RNA replication inhibitor.
J Org Chem
; 69(19): 6257-66, 2004 Sep 17.
Article
em En
| MEDLINE
| ID: mdl-15357584
ABSTRACT
A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the 12-step synthesis features a novel stereoselective rearrangement to prepare the key crystalline furanose diol intermediate. This is followed by a highly selective glycosidation to couple the C-2 branched furanose epoxide with deazapurine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
RNA Viral
/
Hepacivirus
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos