[Separation of enantiomers of phenylcarbamic acid derivatives by HPLC method]. / Separácia enantiomérov--derivátov kyseliny fenylkarbámovej metódou HPLC.
Ceska Slov Farm
; 53(4): 197-202, 2004 Jul.
Article
em Sk
| MEDLINE
| ID: mdl-15369232
ABSTRACT
The chiral stationary phase on the base of beta-cyclodextrin and the mobile phase acetonitrile/0.1 mol/l acetate buffer pH=5.2 (88/12 w/w) were used for the separation of the enantiomers of 1-methoxymethyl, 1-ethoxymethyl, 1-propoxymethyl-2-(1-pyrrolidinyl), (1-piperidino), (1-perhydroazepinyl)ethyl esters of 2-alkoxyphenylcarbamic acid. The influence of the structure of these compounds and the influence of temperature on enantioseparation were studied. The dominant effect on the resolution of enantiomers is exerted by the length of the alkoxysubstituent on the aromatic ring and its position with regard to the stereogenic centre. A decrease in temperature caused an increase in the retention factors of the compounds under study and the resolution values of enantiomers.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbamatos
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Cromatografia Líquida de Alta Pressão
Idioma:
Sk
Revista:
Ceska Slov Farm
Assunto da revista:
FARMACIA
/
FARMACOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article