In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 AND K048.
Acta Medica (Hradec Kralove)
; 47(2): 107-9, 2004.
Article
em En
| MEDLINE
| ID: mdl-15446359
ABSTRACT
We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators - K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide), K027 (1 -(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide) as the potential reactivators of AChE inhibited by cyclosarin. Their reactivation potencies were studied using standard in vitro reactivation test. Rat brain homogenate was used as the source of the enzyme. Oxime K033 seems to be the most potent reactivator of cyclosarin-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of all other tested AChE reactivators.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Acetilcolinesterase
/
Compostos de Piridínio
/
Encéfalo
/
Reativadores da Colinesterase
Limite:
Animals
Idioma:
En
Revista:
Acta Medica (Hradec Kralove)
Assunto da revista:
MEDICINA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
República Tcheca