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Parathyroid hormone--possible future drug for orthopedic surgery.
Aleksyniene, Ramune; Hvid, Ivan.
Afiliação
  • Aleksyniene R; Institute of Experimental Clinical Research, Aarhus University, Denmark. ramunealeks@vision.kmu.lt
Medicina (Kaunas) ; 40(9): 842-9, 2004.
Article em En | MEDLINE | ID: mdl-15456969
Parathyroid hormone naturally secreted by the parathyroid glands is a potent anabolic agent for bone. Parathyroid hormone is primarily thought of as a catabolic protein involved in the physiologic release of calcium from bone. Whereas during recent years, a number of animal studies and clinical trials have demonstrated that intermittent parathyroid hormone administration induces anabolic effects on both cancellous and cortical bone, enhances bone mass and increases mechanical strength of the bones. Most of the studies, both animal and human, have addressed the treatment of osteoporosis and parathyroid hormone represents an important new advance in the therapy of osteoporosis. Few studies have investigated the effect of intermittent parathyroid hormone treatment in the field of orthopedics on fracture healing and fixation of orthopedic implants. The results of those studies indicated an enhancement of fracture healing, faster bone repair and better fixation of the implant. Recently there were few animal studies started to investigate the effects of parathyroid hormone treatment on bone formation in regenerated and surrounding bone of distracted callus during limb lengthening. Distraction osteogenesis is a technique for bone lengthening that is widely used clinically and experimentally. Newly forming bone during distraction osteogenesis is expected to be an appropriate pattern for parathyroid hormone anabolic effect. Preclinical studies as well as clinical trials suggest that parathyroid hormone might be useful as a stimulator of bone formation whereas a lot of questions regarding parathyroid hormone therapy remain unanswered and require further experimental studies and investigations.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ortopedia / Hormônio Paratireóideo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Suíça
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ortopedia / Hormônio Paratireóideo Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Suíça