Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin.
Peptides
; 25(11): 1971-5, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15501529
ABSTRACT
In frog skin, tachykinins stimulate the ion transport, estimated by measuring the short-circuit current (SCC) value, by interacting with NK1-like receptors. In this paper we show that Kassinin (NK2 preferring in mammals) increases the SCC, while Enterokassinin has no effect. Therefore, either 2 Pro residues or 1 Pro and 1 basic amino acid must be present in the part exceeding the C-terminal pentapeptide. Eledoisin (NK3 preferring in mammals) stimulation of SCC is reduced by CP99994 and SR48968 (NK1 and NK2 antagonists) and not affected by SB222200 (NK3 antagonist). None of the three antagonists affects Kassinin stimulation of SCC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rana esculenta
/
Pele
/
Cassinina
/
Taquicininas
/
Eledoisina
/
Transporte de Íons
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Itália