The platelet count accuracy of platelet concentrates obtained by using automated analysis is influenced by instrument bias and activated platelet components.
Vox Sang
; 87(3): 196-203, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15569073
ABSTRACT
BACKGROUND AND OBJECTIVES:
The blood platelet content (in numbers) of platelet concentrates is required for production quality control and to predict clinical responses. MATERIALS ANDMETHODS:
This study compared the performance of automated counting from impedance and optical instruments to data from immunoplatelet reference analysis.RESULTS:
All methods showed good linearity with evidence of significant instrument-specific deviations from the line of agreement. Relational formulae largely corrected bias, but did not resolve platelet count variability. A second confounding factor, related to the proportion of small (activated) platelets, was also shown to contribute to intermethod discrepancies.CONCLUSIONS:
Blood processing centres should establish correction factors for each instrument compared to reference methods, such as the immunoplatelet count.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Contagem de Plaquetas
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Vox Sang
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Noruega
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM