The effect of bioactive glass content on synthesis and bioactivity of composite poly (lactic-co-glycolic acid)/bioactive glass substrate for tissue engineering.
Biomaterials
; 26(14): 1935-43, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15576167
ABSTRACT
Tissue engineering offers a promising new approach to bone tissue grafting. One material that has received attention in this regard is the polymer poly (lactic-co-glycolic acid) (PLGA). It has the advantage of controllable bioresorption and ease of processing. Another material of interest is bioactive glass (BG), which shows the ability to stimulate osteoblastic differentiation of osteoprogenitor cells. In this study, we reported on the optimal synthesis parameters and the kinetics of formation of calcium phosphate (Ca-P) phase at the surface of PLGA/BG composites. The formation of calcium phosphate layer was confirmed using scanning electron microscopy/energy dispersive X-ray analysis (SEM/EDXA). PLGA-30%BG microspheres based porous scaffolds for bone tissue engineering were examined for their ability to promote osteogenesis of marrow stromal cells (MSC). This porous scaffold supported both MSC proliferation and promoted MSC differentiation into cells expressing the osteoblast phenotype. It therefore demonstrates significant potential as a bone replacement material.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
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Ácido Poliglicólico
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Polímeros
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Fosfatos de Cálcio
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Células da Medula Óssea
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Substitutos Ósseos
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Ácido Láctico
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Engenharia Tecidual
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Vidro
Limite:
Animals
Idioma:
En
Revista:
Biomaterials
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos