Monoamine oxidase inhibitors from Gentiana lutea.
Phytochemistry
; 65(15): 2255-60, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15587710
ABSTRACT
Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea. Their structures were elucidated to be 3-3''linked-(2'-hydroxy-4-O-isoprenylchalcone)-(2'''-hydroxy-4''-O-isoprenyldihydrochalcone) (1), 2-methoxy-3-(1,1'-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one and 5-hydroxyflavanone. These compounds, and the hydrolysis product of 1, displayed competitive inhibitory properties against MAO-B which was more effective than MAO-A.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Gentiana
/
Mitocôndrias
/
Monoaminoxidase
/
Inibidores da Monoaminoxidase
Limite:
Animals
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão