Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster.
Nat Neurosci
; 8(1): 15-7, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15592462
ABSTRACT
Despite increasing knowledge about dimerization of G-protein-coupled receptors, nothing is known about dimerization in the largest subfamily, odorant receptors. Using a combination of biochemical and electrophysiological approaches, we demonstrate here that odorant receptors can dimerize. DOR83b, an odorant receptor that is ubiquitously expressed in olfactory neurons from Drosophila melanogaster and highly conserved among insect species, forms heterodimeric complexes with other odorant-receptor proteins, which strongly increases their functionality.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condutos Olfatórios
/
Receptores Odorantes
/
Proteínas de Drosophila
/
Drosophila melanogaster
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Alemanha