Kidney cortical necrosis induced by mitomycin-C: a morphologic experimental study.
Ren Fail
; 14(1): 31-9, 1992.
Article
em En
| MEDLINE
| ID: mdl-1561387
ABSTRACT
Experimental studies on mitomycin-C nephrotoxicity are scanty and mention the occurrence of cortical hemorrhage, tubular necrosis, or hydronephrosis secondary to papillomatous hyperplasia of the uroepithelium. To our knowledge, only one experimental study has mentioned morphological lesions similar to the hemolytic uremic syndrome in the human. In the present study 40 female Wistar rats were studied following unilateral renal perfusion of the left kidney with 2 mg/kg of mitomycin-C. Renal lesions corresponded to cortical necrosis with the presence of large bizarre nuclei. The presence of these nuclear atypias supports a direct toxic effect (alkylation) of the mitomycin or its metabolites on cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mitomicina
/
Necrose do Córtex Renal
Limite:
Animals
Idioma:
En
Revista:
Ren Fail
Assunto da revista:
NEFROLOGIA
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Espanha