On the estimation of genome-wide heterozygosity using molecular markers.
J Hered
; 96(2): 85-8, 2005.
Article
em En
| MEDLINE
| ID: mdl-15618305
ABSTRACT
Coltman and Slate (2003) recently performed a meta-analysis on studies that investigated the association between genetic variation at microsatellite loci and phenotypic trait variation. One factor not explicitly addressed in their meta-analysis is the actual estimation of genome-wide heterozygosity via molecular markers. Many authors still associate marker-estimated heterozygosity with genome-wide heterozygosity, despite allozyme-based evidence that such correlations are usually very weak or nonexistent. Here, we show that genome-wide heterozygosity is poorly estimated not only by allozymes but also by microsatellite loci and by single-nucleotide polymorphisms (SNPs). Thus, associations between fitness (or other phenotypes) and heterozygosity should be established firmly on causative factors and not on simple correlations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma
/
Triagem de Portadores Genéticos
/
Modelos Genéticos
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Idioma:
En
Revista:
J Hered
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos