Fluoxetine attenuates adrenocortical but not subjective responses to cocaine cues.
Am J Drug Alcohol Abuse
; 30(4): 765-82, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15624548
ABSTRACT
Preclinical data suggest a link between stress reactivity and cocaine self-administration by rodents. Serotonin appears to modulate the hypothalamic-pituitary-adrenal (HPA) axis. We studied the effects of chronic treatment with the serotonin reuptake inhibitor fluoxetine 40 mg/day on subjective and hormonal responses to cocaine cues in 22 subjects participating in a controlled clinical trial for cocaine dependence. Fluoxetine antagonized the cue-induced increase in cortisol but increased subjects' ratings of the likelihood of cocaine use in response to cocaine cues. Cortisol response to cocaine cues was not related to subjective craving. Activation of the HPA axis by cocaine cues does not appear to be a necessary mediator of cue-induced craving.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Hidrocortisona
/
Fluoxetina
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Inibidores Seletivos de Recaptação de Serotonina
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Transtornos Relacionados ao Uso de Cocaína
/
Motivação
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Am J Drug Alcohol Abuse
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos