Pharmacokinetics of terfenadine in healthy elderly subjects.
J Clin Pharmacol
; 32(3): 267-71, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1564131
ABSTRACT
The pharmacokinetics of the terfenadine active metabolite, metabolite I, was examined in ten healthy elderly adults and ten younger adults after single-dose oral administration of 120-mg terfenadine. All subjects successfully completed the study without reporting sedation or other adverse events. Absorption was rapid in both the young and elderly. The mean Cmax was the same for both groups, 501 ng/mL, and occurred at 2.3 hours in the young subjects and 2.5 hours in elderly subjects. However, the apparent clearance was reduced by about 25% in the elderly. After correcting clearance for bodyweight, this difference was not statistically significant.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terfenadina
Limite:
Adult
/
Aged
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article