Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251.
J Immunol
; 174(4): 2185-9, 2005 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-15699150
ABSTRACT
Effector cells armed with Abs can eliminate virus-infected target cells by Ab-dependent cellular cytotoxicity (ADCC), an immune mechanism that has been largely overlooked in HIV vaccine development. Here, we show that a prime/boost AIDS vaccine approach elicits potent ADCC activity correlating with protection against SIV in rhesus macaques (Macacca mulatta). Priming with replicating adenovirus type 5 host range mutant-SIV recombinants, followed by boosting with SIV gp120, elicited Abs with ADCC activity against SIV(mac251)-infected cells. In vitro ADCC activity correlated with in vivo reduced acute viremia after a mucosal challenge with pathogenic SIV. Our findings expose ADCC activity as an immune correlate that may be relevant in the rational design of an efficacious vaccine against HIV.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viremia
/
Vírus da Imunodeficiência Símia
/
Vacinas contra a SAIDS
/
Anticorpos Antivirais
/
Citotoxicidade Celular Dependente de Anticorpos
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos