Th1/Th2 polarization by viral and helminth infection in birds.
Vet Microbiol
; 105(3-4): 163-7, 2005 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-15708812
ABSTRACT
Mammals developed an immune system able to functionally polarize into so-called type 1 or type 2 immune pathways, to resolve infections with intracellular and extracellular pathogens, respectively. In the well-studied avian immune system of the chicken, however, no evidence for polarized immunity could be found, as yet. To investigate whether these two major arms of mammalian immunity, regulated by a T helper (Th)1/Th2 cytokine balance, evolved similarly in birds, chickens were exposed to a prevalent intracellular (viral) or extracellular (helminth) infection. By using semi-quantitative RT-PCR analysis we provide evidence that polarization of Th1/Th2 type immunity extends beyond mammalian species, and, therefore, has been evolutionary conserved for more than 300 million years, when the lineages of mammalian and avian vertebrates are assumed to have segregated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Aves Domésticas
/
Ascaridíase
/
Galinhas
/
Células Th2
/
Células Th1
/
Doença de Newcastle
Limite:
Animals
Idioma:
En
Revista:
Vet Microbiol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Holanda