Antitumor metallothiosemicarbazonates: structure and antitumor activity of palladium complex of phenanthrenequinone thiosemicarbazone.
Inorg Chem
; 44(5): 1154-6, 2005 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-15732942
ABSTRACT
The crystal structure of the potential antitumor metal compound, viz. chloro, mono(phenanthrenequinone thiosemicarbazonato) palladium(II) dimethyl formamide solvate, is reported. The central palladium(II) atom is in a square planar environment provided by the tridentate, monoanionic thiosemicarbazone ligand and the ancillary chloride ion. The compound exhibited remarkable activity against drug-sensitive and drug-resistant breast cancer cell lines and was relatively nontoxic toward the normal mammary epithelial cells. The drug-induced killing effect against breast cancer cell lines was predominantly mediated via apoptosis, a physiologic form of cell death.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenantrenos
/
Tiossemicarbazonas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Inorg Chem
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos