Choline acetyltransferase activity in murine thymus.
J Neurosci Res
; 31(2): 380-6, 1992 Feb.
Article
em En
| MEDLINE
| ID: mdl-1573686
ABSTRACT
Murine thymus has been demonstrated to contain both cholinergic receptors and acetylcholinesterase activity. In the present study we have investigated the presence of the enzyme choline acetyltransferase in this organ, which is responsible for the synthesis of acetylcholine. Results reported here demonstrate that (1) an appreciable amount of the enzyme is already present in the thymus on the day of birth; (2) its expression is developmentally regulated; and (3) thymic atrophy, induced in young (2-week-old) and adult (6-week-old) mice by i.p. injection of hydrocortisone for 2 days, is accompanied by significant reduction of choline acetyltransferase activity only in young mice. Altogether these results demonstrate the presence in the murine thymus of functionally relevant markers of the cholinergic system that might interface the interactions between the nervous and immune systems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Colina O-Acetiltransferase
Limite:
Animals
Idioma:
En
Revista:
J Neurosci Res
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália