Your browser doesn't support javascript.
loading
Expression of myeloid differentiation antigens in acute nonlymphocytic leukemia: increased concentration of CD33 antigen predicts poor outcome--a report from the Childrens Cancer Study Group.
Dinndorf, P A; Buckley, J D; Nesbit, M E; Lampkin, B C; Piomelli, S; Feig, S A; Kersey, J H; Hammond, G D; Bernstein, I D.
Afiliação
  • Dinndorf PA; Fred Hutchinson Cancer Research Center, Seattle, Washington.
Med Pediatr Oncol ; 20(3): 192-200, 1992.
Article em En | MEDLINE | ID: mdl-1574028
ABSTRACT
Ninety-eight cryopreserved specimens of acute nonlymphocytic leukemia (ANLL) cells obtained at initial diagnosis of children enrolled on the Childrens Cancer Study Group 251 protocol (CCG 251) were examined by indirect immunofluorescence using four monoclonal antibodies to myeloid differentiation antigens. The relationship between the level of differentiation of ANLL cells as determined by their antigen phenotype and the clinical outcome of treatment, including complete remission (CR) rate, survival, and event-free survival, was evaluated. Most leukemic specimens were determined to express the CD33 antigen (L4F3), a 67-kD protein. Because the level of differentiation of normal myeloid cells is reflected by the concentration of the CD33 antigen expressed, samples were categorized as CD33-bright (immature) versus CD33-dull (mature). Patients with CD33-bright leukemic blasts had a marginally inferior CR rate to those with CD33-dull blasts (P = 0.08). With respect to survival and event-free survival, there was a significantly inferior outcome in the CD33-bright patients (P = 0.04 and P = 0.06, respectively). Reactions of ANLL with anti-CD15 antibody (1G10), anti-CD36 antibody (5F1), or anti-CD17 antibody (T5A7) did not predict clinical outcome. This study indicates that patients whose ANLL blasts displayed the CD33 antigen in an amount associated with immature myeloid cells experienced a worse outcome than patients with ANLL blasts that expressed a phenotype associated with more mature cells.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Diferenciação Mielomonocítica / Leucemia Mieloide Aguda / Antígenos CD Tipo de estudo: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: Med Pediatr Oncol Ano de publicação: 1992 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Diferenciação Mielomonocítica / Leucemia Mieloide Aguda / Antígenos CD Tipo de estudo: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: Med Pediatr Oncol Ano de publicação: 1992 Tipo de documento: Article