Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin.
Eur J Pharmacol
; 512(1): 9-13, 2005 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-15814084
ABSTRACT
Forskolin and cAMP have been shown to have paradoxical effects in the regulation of expression levels of mRNA of cytochrome P450 3A (CYP3A) family members. We demonstrate in this study that forskolin upregulated the promoter for CYP3A4 independent of its ability to increase cAMP levels. This activity was explained showing forskolin directly activated the pregnane-X-receptor, a known regulator of CYP3A genes.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colforsina
/
AMP Cíclico
/
Sistema Enzimático do Citocromo P-450
Limite:
Humans
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS