Early behavioral symptoms and course of Alzheimer's disease.
Acta Psychiatr Scand
; 111(5): 367-71, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15819730
ABSTRACT
OBJECTIVE:
To determine if behavioral symptoms detected at initial evaluation relate to cognitive or functional status or survival time in Alzheimer's disease (AD) patients.method:
Review, in 100 cases of autopsy-proven AD, of the relationship of behavioral symptoms detected at initial evaluation to cognitive and global function measures and survival time.RESULTS:
Behavioral symptoms had occurred in 74% of patients, including apathy (51%), hallucinations (25%), delusions (20%) and depressed mood (6.6%). Verbal aggression was common (36.8%); physical aggression less so (17%). The symptomatic group was more functionally (but not cognitively) impaired and had shorter median survival time (8 years 95% CI 7-9 years vs. 10 years 95% CI 8-12 years; P = 0.002) than the asymptomatic group. The presence of any one symptom at initial evaluation accounted for 6.1% of the variance in duration of illness.CONCLUSION:
Presence of behavioral symptoms at initial evaluation of AD patients is associated with greater functional impairment and shorter survival time.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sintomas Comportamentais
/
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos