Neurovirulence of H7N7 influenza A virus: brain stem encephalitis accompanied with aspiration pneumonia in mice.
Arch Virol
; 150(8): 1653-60, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-15841337
ABSTRACT
A mouse-adapted influenza A virus, A/equine/London/1416/73-MA (H7N7) caused viral pneumonia, ganglionitis and encephalitis after intranasal inoculation in mice. Virological and pathological data suggested that this virus spreads to the brain by both hematogenous and transneuronal routes, and produces encephalitic lesions similar to those seen in mice infected with H5 highly pathogenic avian influenza A viruses by intranasal infection. Some mice infected with this strain were affected by aspiration pneumonia, which may be caused by neurogenic dysfunction of the pharyngeal/laryngeal reflex due to brain stem encephalitis.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Pneumonia
/
Encéfalo
/
Infecções por Orthomyxoviridae
/
Encefalite Viral
/
Vírus da Influenza A Subtipo H7N7
Limite:
Animals
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Japão