[The differential expression of hypoxia-inducible factor-1alpha in placenta tissues from pregnancy induced hypertension and normal pregnancy].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 21(3): 362-4, 2005 May.
Article
em Zh
| MEDLINE
| ID: mdl-15862159
ABSTRACT
AIM:
To explore the differential expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in placenta tissues from pregnancy induced hypertension and normal pregnancy.METHODS:
The expression of HIF-1alpha protein and mRNA was detected by Western blot and real-time PCR, respectively.RESULTS:
As compared with the expression levels of HIF-1alpha protein and mRNA in placenta tissues from normal pregnancy, those from pregnancy induced hypertension increased notably (P<0.05).CONCLUSION:
The high expression of HIF-1alpha in the placenta tissues pregnancy induced may relate with pathogenesis and pathophysiological process of hypertension.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Regulação da Expressão Gênica
/
Hipertensão Induzida pela Gravidez
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
Zh
Revista:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China