IgG neuropathy: an immunoelectron microscopic study.
J Neuropathol Exp Neurol
; 64(5): 386-90, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15892295
ABSTRACT
There are many potential mechanisms of peripheral nerve impairment by a monoclonal IgG dysglobulinemia. In this study, using electron microscopy, we observed widening of the myelin lamellae comparable to that commonly described in IgM neuropathies with antimyelin-associated glycoprotein activity. Such features have yet to be described in IgG neuropathies. In addition, we observed deposits of a granular material in the interstitial tissue of the nerve. By immunoelectron microscopy, we demonstrated the presence of the IgG in the lesions of myelin and the endoneurial space. A direct link between monoclonal dysglobulinemia (regardless of type) and polyneuropathy should be confirmed by nerve biopsy, because the result may influence treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polineuropatias
/
Imunoglobulina G
/
Microscopia Imunoeletrônica
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Neuropathol Exp Neurol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
França