Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum.
Phytochemistry
; 66(10): 1113-20, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15913675
ABSTRACT
One bi-bicyclic and two bi-tricyclic derivatives of coumarin-benzofuran, phenanthrene-phenanthrene and phenanthrene-phenanthraquinone, along with seven known compounds, were isolated from stems of Dendrobium thyrsiflorum Rchb.f. (Orchidaceae). On the basis of chemical, NMR (1H, 13C, HMQC, HMBC and NOESY) and mass spectrometry data, their structures were elucidated as denthyrsin [3-(5',6'-dimethoxybenzofuran-2'-yl)-6,7-dimethoxy-2H-chromen-2-one; 1], denthyrsinol (4,5'-dimethoxy-[1,1']biphenanthrenyl-2,5,4',7'-tetraol; 2), and denthyrsinone (7,4',7'-trihydroxy-2,2',8'-trimethoxy-[5,1']biphenanthrenyl-1,4-dione; 3). Compounds 1-3 and denthyrsinin (1,5,7-trimethoxyphenanthrene-2,6-diol; 4) showed significant cytotoxic activities against Hela (13.5, 9.3, 9.9 and 2.7 microM, respectively), K-562 (0.45, 1.6, 6.0 and 2.3 microM, respectively) and MCF-7 (18.1, not tested, 3.5 and 4.8 microM, respectively) cell lines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dendrobium
/
Hidrocarbonetos Cíclicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China