Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity.
J Inorg Biochem
; 99(7): 1526-31, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-15927263
ABSTRACT
Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. The X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Semicarbazonas
/
Tiossemicarbazonas
/
Naftoquinonas
/
Níquel
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos