Early signs of cognitive deficits among human immunodeficiency virus-positive hemophiliacs.
Acta Psychiatr Scand
; 85(4): 321-6, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1595365
ABSTRACT
A total of 181 human immunodeficiency virus (HIV)-seropositive hemophiliacs and 28 hemophilic controls were evaluated by psychometric tests and by electroencephalogram (EEG). Patients were classified from stages 1-6 according to the immunological criteria of the Walter Reed staging system. Statistical analysis of psychometric data showed an effect of the stage of the disease on test performances, indicating a decline in attention, accumulation of perceptual interferences, decline in visuoperceptual speed and visuomotor response speed and reduced verbal memory performance, especially in stage 6 patients. Comparison of performance levels with normative test data already revealed cognitive deficits in about 20-30% of the patients in stages 2-5. As regards verbal memory, especially learning and recognition of new verbal information were impaired. In contrast, there was no significant deficit for nonverbal memory processing. Compared with the controls, patients exhibited an increasing number of abnormal EEG findings in stages 2-6. As a conclusion, in the stages before acquired immunodeficiency syndrome (AIDS) develops, EEG findings as well as psychometric findings indicate central nervous system involvement of AIDS in about 20-30% of cases, whereas in full-blown AIDS there is a marked increase to 80%. Besides a more general deficit of attention and psychomotor speed as is seen in subcortical dementia, there is evidence for a particular verbal learning disorder, suggesting additional selective impairment of the brain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complexo AIDS Demência
/
Soropositividade para HIV
/
Transtornos Cognitivos
/
Hemofilia A
/
Testes Neuropsicológicos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Alemanha